Tachyphylaxis with desmopressin

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August undefined, 2024

WebSummary When patients with mild haemophilia or von Willebrand disease (vWD) are repeatedly treated with desmopressin (DDAVP) at relatively short time intervals, some of … WebDesmopressin (1-deamino-8-d -arginine vasopressin (DDAVP)) is a synthetic analogue of the antidiuretic hormone 8-arginine vasopressin. DDAVP stimulates the vasopressin V2 receptor, which causes water retention and the release of FVIII and vWF from endothelium. DDAVP has been used in mild hemophilia and type I vWD (decreased multimers of vWF).

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WebSep 1, 2024 · Tachyphylaxis (lessening of response) with repeated administration (i.e., given more frequently than every 48 hours) may occur. The initial response is reproducible if DDAVP is administered every 2 to 3 … Webmoderate disease, on-demand treatment with desmopressin is an effective option for raising endogenous VWF levels. As such, des-mopressin and/or tranexamic acid are often used for minor surgical procedures, including dental work. 5,7 In some patients, the response to desmopressin decreases after repeated doses (tachyphylaxis) with reduced ... food delivery in hoxton

DailyMed - DESMOPRESSIN ACETATE injection

WebFeb 15, 2024 · Results: Rates of tachyphylaxis varied from 9% to 57% depending on the patient population and duration of follow-up. Limited evidence suggests potentially beneficial strategies for managing tachyphylaxis, including change in antidepressant dosing, switch of class of antidepressant medication, augmentation or combination … WebAnaphylaxis has been reported rarely with intravenous and intranasal desmopressin acetate, including isolated cases of fatal anaphylaxis with intravenous desmopressin acetate. It is not known whether antibodies to Desmopressin Acetate Injection 4 mcg/mL are produced after repeated injections. WebDesmopressin. Desmopressin (1-desamino-8-d -arginine vasopressin [DDAVP]) is a synthetic analogue of ADH released by the posterior pituitary gland that reduces urine production by increasing water reabsorption by the collecting tubules. DDAVP has been used to treat enuresis for the past 40 years. elasticsearch search explain

Von Willebrand Disease: Range of the Disease, and Management

Sun Pharmaceutical Industries Limited DESMOPRESSIN …

WebDesmopressin. 423 Parenteral desmopressin was originally formulated at a concentration of 4 μg/mL, to be used at a 0.3-μg/kg/dose to treat bleeding diatheses such as hemophilia A and von Willebrand disease type 1. ... but tachyphylaxis may occur after three or four doses, 37 limiting further usefulness of DDAVP. WebDesmopressin is an analog of vasopressin that exerts a substantial haemostatic effect by inducing the release of von Willebrand factor from its storage sites in endothelial cells. It has proved useful in treating or preventing bleeding episodes in patients with von Willebrand disease, haemophilia A and platelet function defects. Its efficacy in achieving a … food delivery in hospitalWebDesmopressin is an analog of vasopressin that exerts a substantial haemostatic effect by inducing the release of von Willebrand factor from its storage sites in endothelial cells. It … elasticsearch search guard

"Webtachyphylaxis: ( tak'i-fī-lak'sis ), Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active … " - Tachyphylaxis with desmopressin

Tachyphylaxis with desmopressin

Desmopressin treatment combined with clotting factor VIII …

WebVon Willebrand Disease: Range of the Disease, and Management WebJun 18, 2024 · Tachyphylaxis is a decrease in the therapeutic effect of medications when they are re—administered. The condition is most often found with the use of …

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WebSummary When patients with mild haemophilia or von Willebrand disease (vWD) are repeatedly treated with desmopressin (DDAVP) at relatively short time intervals, some of them may become less responsive or unresponsive. The development of tachyphylaxis would limit the usefulness of DDAVP in clinical management of these patients. WebUsed for the treatment of central diabetes insipidus, primary nocturnal enuresis (PNE), spontaneous bleeding or trauma-induced hemorrhage, bleeding prophylaxis (e.g., surgical …

WebNov 20, 2012 · Patients can develop tachyphylaxis to desmopressin, rendering this agent of limited utility with repeated use.[11,12] 2. Administration and Pharmacokinetics. Desmopressin can be given intranasally, intravenously, subcutaneously or orally. The usual antidiuretic dose is 10–20μg intranasally (with a bioavailability of 10–20% from this ...

WebApr 9, 2024 · Ferraris VA, Boral LI, Cohen AJ, Smyth SS, White GC 2nd. Consensus review of the treatment of cardiovascular disease in people with hemophilia A and B. Cardiol Rev. 2015 Mar-Apr;23(2):53-68. doi: 10.1097/CRD.0000000000000045. WebDesmopressin (DDAVP) 0.4mcg/kg (maximum 40mcg) in 50mL Normal Saline to be infused over 15 minutes • Tachyphylaxis with reduced efficacy and potential for increased bleeding time may occur with repeat doses • •Do NOT give more than 2 doses in any 48 hour time period • History of

WebAdministration of DDAVP for hemostasis. Adequate response to a test dose is ideally established before use, but a patient with AVWS and acute bleeding may receive the first …

WebDesmopressin (1-deamino-8-D-arginine vasopressin [DDAVP]) is a synthetic analog of vasopressin (commonly known as anti-diuretic hormone). It has been used in several diseases ... Diminished efficacy (tachyphylaxis) can occur with repeated desmopressin doses, as storage pools are depleted with repeated administration[91]. elasticsearch search highlightWebAims: To study desmopressin response in hemophilia A patients who received repeated doses perioperatively and to determine extent and determinants of tachyphylaxis. … elasticsearch search from multiple indexWebDDAVP (desmopressin), either intravenously or by nasal spray (Stimate), is often helpful for patients with a platelet function defect (see Chapter 67 for details). There should be a … elasticsearch search limit 10WebApr 26, 2024 · The tendency toward tachyphylaxis (lessening of response) with repeated administration given more frequently than every 48 hours should be considered in treating each patient. ... Desmopressin Acetate Injection 4 mcg/mL dosage must be determined for each patient and adjusted according to the pattern of response. Response should be … elasticsearch search preferenceWebMay 22, 2002 · Desmopressin is a fast-acting blood-saving agent used in various hereditary and acquired clotting disorders. We used desmopressin infusions to treat massive pulmonary hemorrhage in six leptospirosis patients with respiratory failure, shock, and multiple organ dysfunction. ... in which tachyphylaxis occurs after three or four doses. … elasticsearch search nested fieldWebdeveloping tachyphylaxis. Plasma-derived VWF/FVIII concentrates These products, with the characteristics summa-rized in Table 1, are recommended at the dosages shown in Table 26 in cases with no or inadequate response to DDAVP. Table 3 summarizes data on the efficacy of VWF/FVIII for short-term bleeding prophylaxis in patients undergoing surgery or elasticsearch search not nullWebSep 30, 2024 · Desmopressin Acetate Injection USP is a vasopressin analog used for: Central Diabetes Insipidus - as antidiuretic replacement therapy in the management of … elasticsearch search engine