Klf9 function
WebAltered Krüppel-like factor 9 (KLF9) expression can regulate the progression of several cancers, including renal cell carcinoma (RCC). This study was conducted to investigate … WebMar 1, 2024 · 3. The function of KLFs in breast cancer3.1. KLFs in cell proliferation. Cell proliferation is one of the important physiological functions of living cells and an …
Klf9 function
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WebJan 1, 2024 · KLF9 influences the expression of uterine epithelial genes through mechanisms likely involving its transcriptional activator and repressor functions and … WebNov 1, 2024 · In turn, forced expression of KLF9 altered the baseline and GC/E2-responsive expression of several clock genes, indicating that KLF9 may function as a regulator of the core clock machinery.
WebCongenital hypothyroidism (CH) is one of the most prevalent endocrine diseases and is often accompanied by anemia and immunodeficiency in patients, for which the underlying mechanisms remain unknown. Here we created a severe CH model together with WebOct 6, 2024 · While Klf9 has been implicated in both transcriptional activation and repression in different contexts ( Mitchell and Dimario, 2010 ), it functions predominantly as a …
WebMar 1, 2024 · KLF9 recedes MMP9 by antagonizing NF-κB p50/p65 binding to the promoter of MMP9. In addition to MMP9, KLF9 also down-regulated several other NF-κB targets such as TNF-α, VEGFA and uPA in breast cancer cells [ 68 ]. 3.3.3. Invasion KLFs are also implicated in the invasion of breast cancer cells. WebKLF9 INFORMATION. Proteini. Full gene name according to HGNC. Kruppel like factor 9. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. KLF9 (BTEB1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).
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WebSep 7, 2012 · KLF9 may play a key role in GC actions on hippocampal development and plasticity. The hippocampus is an important target for the actions of circulating glucocorticoids (GC). lifelabs in downtown torontoWebBortezomib, a therapeutic agent for multiple myeloma (MM) and mantle cell lymphoma, suppresses proteosomal degradation leading to substantial changes in cellular transcriptional programs and ultimate mct brain icd10WebSince Klf9 expression occurs predominantly in the pre-receptive stroma, this suggests a role for KLF9 in stromal-epithelial cross-talk important for endometrial receptivity. ... KLF9's function as a molecular brake for BMP2 could be manipulated to advance uterine receptivity in clinical conditions where delayed endometrial maturation may lead ... lifelabs in essex ontarioWebAug 20, 2010 · KLF9 functions in adipogenesis at the middle stage of 3T3-L1 adipocyte differentiation To address the function of KLF9 in adipogenesis, we established five stable cell lines containing... life labs in cobourg ontWebNov 16, 2024 · KLF9 acts as a critical mediator between the thyroid axis and hematopoiesis. Visual Abstract View large Download slide Abstract Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases, for which the underlying mechanisms remain unknown; it is often accompanied by anemia and immunodeficiency in patients. mctb morhangeWebFeb 16, 2024 · Meanwhile, the luciferase assay showed that Krüppel-like transcription factor 9 (KLF9) was the downstream target of miR-93-5p. Forced expression of KLF9 blocked the function of miR-93-5p on H/R-treated HK-2 cells. Knockdown of circHIPK3 improved the renal function and reduced the apoptosis level in vivo. In conclusion, circHIPK3 … lifelabs in duncan bcWebOct 27, 2024 · Aims: Krüppel-like Factor 9 (KLF9) is a transcription factor that regulates multiple disease processes. Studies have focused on the role of KLF9 in the redox system. In this study, we aimed to explore the effect of KLF9 on diabetic cardiomyopathy. Methods and Results: Cardiac-specific overexpression or silencing of KLF9 in C57BL/6 J … lifelabs ingersoll ave woodstock