WebBioorthogonal chemistry is a field in which click reactions are used to carry out chemical transformations inside biological cells. The technique offers a new way to study the natural processes taking place in cells and might even provide new ways to deliver drug molecules to specific cells with incredible levels of precision. WebApr 1, 2015 · Bioorthogonal reactions are chemical modifications that can be performed within living biological systems, such as cultured mammalian cells or even complex organisms (e.g. zebra fish or mice) without interfering with its host biochemistry. ... Building better bioorthogonal reactions. Curr Opin Chem Biol, 21 (2014), pp. 103-111.
Building better bioorthogonal reactions. - Abstract
WebApr 8, 2024 · Nature chemical biology 2024, 13 (7), 697–705; [Google Scholar] (h) Shih HW; Kamber DN; Prescher JA, Building better bioorthogonal reactions. Current opinion in chemical biology 2014, 21, 103–11; [Google Scholar] (i) Sletten EM; Bertozzi CR, Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Webreactions constituted the most important part of the click chemistry concept. As the article title implies, these reactions should essentially lead to the building blocks ‘clicking’ together as a belt is locked in by a belt buckle. Each reaction should be straightforward and lead efficiently to the desired connection. 80 指挥体系 13354
Increasing the Efficacy of Bioorthogonal Click Reactions for ...
WebClick reactions have revolutionised chemistry as a robust and reliable way to join small modular units together. Most importantly, they can be made to be biocompatible. Such bioorthogonal reactions allow scientists to track biological processes inside living organisms without disturbing their natural functions. WebOct 5, 2024 · “These are robust, efficient reactions that always work, regardless the environment, even in living systems,” says Petr Beier of the Institute of Organic Chemistry and Biochemistry of the Czech Academy … WebOct 13, 2012 · The azide–dibenzocyclooctyne and trans-cyclooctene–tetrazine cycloadditions are both bioorthogonal and mutually orthogonal: trans-cyclooctene derivatives greatly prefer to react with tetrazines rather than azides, while dibenzocyclooctyne derivatives react with azides but not with tetrazines under … 80 教育